Ms. Radhika R, Dr. Rajesh M, Prof . Andrew John Silvester S
INDIAN JOURNAL OF ALLIED HEALTH SCIENCE (IJAHS)
Volume 2,
Issue 2, 2026,
Pages 100 - 110
Background: Left ventricular diastolic dysfunction (LVDD) is an early manifestation of myocardial aging and a precursor of heart failure with preserved ejection fraction (HFpEF).
Methods: This cross-sectional study included 204 participants aged 30-70 years. Transthoracic echocardiography was performed according to ASE/EACVI guidelines using Doppler and tissue Doppler imaging. Statistical analysis included Chi-square test, multivariate logistic regression, and ROC curve analysis.
Results: LVDD prevalence increased from 30.4% (30-39 years) to 84.6% (60-70 years). Age was significantly associated with LVDD (p = 0.001) and was an independent predictor (AOR = 2.18, 95% CI: 1.42-3.35, p = 0.001). Hypertension (AOR = 1.89) and BMI (AOR = 1.36) were also significant predictors. ROC analysis showed good predictive ability of age (AUC = 0.82) with an optimal cut-off of 52 years.
Conclusion: Age is a strong independent predictor of LVDD, and echocardiography enables early detection of subclinical dysfunction.
Left Ventricular Diastolic Dysfunction, LVDD, Echocardiography, Aging Heart, Diastolic Function, Tissue Doppler Imaging, Heart Failure with Preserved Ejection Fraction, HFpEF, Cardiovascular Aging, Hypertension, Body Mass Index, Cardiac Assessment
