Ms. Amirtha P, Dr Anandsekar G, Ms. Subashini B, Prof Andrew John Silvester S
INDIAN JOURNAL OF ALLIED HEALTH SCIENCE (IJAHS)
Volume 2,
Issue 3, 2026,
Pages 251 - 264
Background: Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease, with left ventricular diastolic dysfunction occurring early in disease progression. Tissue Doppler Imaging (TDI)-derived E/e′ ratio is a reliable non-invasive marker of left ventricular filling pressure (LVFP).
Methods: This prospective cross-sectional study included 33 adults with CKD Stages 3-5. Transthoracic echocardiography with TDI was performed to assess LVFP using the E/e′ ratio. The association between LVFP and CKD stage was analyzed using the Chi-square test.
Results: The mean age was 51.55 ± 11.68 years, and 60.6% were males. Stage 5 CKD was most common (51.5%). Normal LVFP was observed in 60.6% of patients, while 39.4% had abnormal LVFP. The mean E/e′ ratio was 8.17 ± 3.12, and mean left ventricular ejection fraction was 50.91 ± 9.32%. No significant association was found between CKD stage and LVFP (p = 0.626).
Conclusion: TDI-derived E/e′ ratio is a valuable non-invasive tool for assessing LVFP and identifying early cardiac dysfunction in CKD patients.
Assessment of left ventricular filling pressure, echocardiography, chronic kidney disease, CKD, tissue Doppler imaging, diastolic dysfunction, left ventricular filling pressure, transthoracic echocardiography, cardiovascular complications, renal disease, cardiac function.
