Sjogren’s syndrome is a chronic autoimmune disorder in which the immune system targets the body’s own moisture-producing glands, leading to systemic dehydration affecting multiple organs. The disease is characterized by lymphocytic infiltration of the lacrimal and salivary glands, resulting in keratoconjunctivitis sicca and xerostomia, which represent the primary clinical manifestations. Additional features include vaginal dryness, non-productive cough, salivary gland enlargement, and systemic symptoms such as arthralgia, fatigue, and generalized discomfort.
REFERENCES:
1.Atzeni F, Gozza F, Cafaro G, Perricone C, Bartoloni E. Cardiovascular Involvement in Sjögren's Syndrome. Front Immunol. 2022 May 6;13:879516. doi: 10.3389/fimmu.2022.879516. PMID: 35634284; PMCID: PMC9134348.
2.Sung MJ, Park SH, Kim SK, Lee YS, Park CY, Choe JY. Complete atrioventricular block in adult Sjögren's syndrome with anti-Ro autoantibody. Korean J Intern Med. 2011 Jun;26(2):213-5. doi: 10.3904/kjim.2011.26.2.213. Epub 2011 Jun 1. PMID: 21716914; PMCID: PMC3110856.
3.Casian M, Jurcut C, Dima A, Mihai A, Stanciu S, Jurcut R. Cardiovascular Disease in Primary Sjögren's Syndrome: Raising Clinicians' Awareness. Front Immunol. 2022 Jun 9;13:865373. doi: 10.3389/fimmu.2022.865373. PMID: 35757738; PMCID: PMC9219550.
4.Bartoloni E, Alunno A, Cafaro G, Valentini V, Bistoni O, Bonifacio AF, Gerli R. Subclinical Atherosclerosis in Primary Sjögren's Syndrome: Does Inflammation Matter? Front Immunol. 2019 Apr 17;10:817. doi: 10.3389/fimmu.2019.00817. PMID: 31110500; PMCID: PMC6499202.
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